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1

Pharmacokinetics of fostamatinib, a spleen tyrosine kinase (SYK) inhibitor, in healthy human subjects following single and multiple oral dosing in three phase I studies

Baluom, Muhammad, Grossbard, Elliott B., Mant, Tim, Lau, David T. W.

Journal:

British Journal of Clinical Pharmacology

Year:

2013

Language:

english

File:

PDF, 461 KB

english, 2013

2

Albuterol HFA is as effective as albuterol CFC in preventing exercise-induced bronchoconstriction

Hawksworth, Richard J., Sykes, Andrew P., Faris, Melissa, Mant, Tim, Lee, Tak H.

Journal:

Annals of Allergy, Asthma & Immunology

Year:

2002

Language:

english

File:

PDF, 154 KB

english, 2002

3

Is there a role of synovial biopsy in drug development?

Filkova, Maria, Cope, Andrew, Mant, Tim, Galloway, James

Journal:

BMC Musculoskeletal Disorders

Year:

2016

Language:

english

File:

PDF, 1.01 MB

english, 2016

4

Developing clinical trial protocols: The use of patient focus groups

Jane Bradburn, Jane Maher, Ruth Adewuyi-Dalton, Eva Grunfeld, Tim Lancaster, David Mant

Journal:

Psycho-Oncology

Year:

1995

Language:

english

File:

PDF, 418 KB

english, 1995

5

Polymer microarrays: Identification of substrates for phagocytosis assays

Alexandra Mant, Guilhem Tourniaire, Juan J. Diaz-Mochon, Tim J. Elliott, Anthony P. Williams, Mark Bradley

Journal:

Year:

2006

Language:

english

File:

PDF, 502 KB

english, 2006

6

Ipecacuanha-induced emesis: A human model for testing antiemetic drug activity

Minton, Neil, Swift, Rachel, Lawlor, Caroline, Mant, Tim, Henry, John

Journal:

Clinical Pharmacology & Therapeutics

Year:

1993

Language:

english

File:

PDF, 749 KB

english, 1993

7

The pathway of cross-presentation is influenced by the particle size of phagocytosed antigen

Alexandra Mant, Fay Chinnery, Tim Elliott, Anthony P. Williams

Journal:

Year:

2012

Language:

english

File:

PDF, 1.18 MB

english, 2012

8

Effect of Oral Posaconazole on the Pharmacokinetics of Cyclosporine and Tacrolimus

Dr. Angela Sansone-Parsons, Dr. Gopal Krishna, Ms. Monika Martinho, Ms. Bhavna Kantesaria, Dr. Steven Gelone, Dr. Tim G. Mant

Journal:

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy

Year:

2007

Language:

english

File:

PDF, 89 KB

english, 2007

9

Two single-center, double-blind, randomized, placebo-controlled, phase i studies to investigate the tolerability and pharmacokinetics of ch-1504, an antifolate, in healthy male subjects

Tim Mant, Stipo Jurcevic, Cameron Szakacs, Luthando Adams, John Boland, Lawrence Arthur Hewitt

Journal:

Clinical Therapeutics

Year:

2008

Language:

english

File:

PDF, 193 KB

english, 2008

10

DNA vaccination protects against an influenza challenge in a double-blind randomised placebo-controlled phase 1b clinical trial

Suzanne Jones, Kirsten Evans, Hilary McElwaine-Johnn, Michaela Sharpe, John Oxford, Rob Lambkin-Williams, Tim Mant, Andrew Nolan, Maria Zambon, Joanna Ellis, John Beadle, Peter T. Loudon

Journal:

Year:

2009

Language:

english

File:

PDF, 817 KB

english, 2009

11

Inhibition of mast cell tryptase by inhaled APC 366 attenuates allergen-induced late-phase airway obstruction in asthma

Krishna, Mamidipudi Thirumala, Chauhan, Anoop, Little, Louise, Sampson, Karen, Hawksworth, Richard, Mant, Tim, Djukanovic, Ratko, Lee, Tak, Holgate, Stephen

Journal:

Journal of Allergy and Clinical Immunology

Year:

2001

Language:

english

File:

PDF, 110 KB

english, 2001

12

Corticosteroid injection for shoulder pain: single-blind randomized pilot trial in primary care

Holt, Tim A, Mant, David, Carr, Andrew, Gwilym, Stephen, Beard, David, Toms, Christy, Yu, Ly-Mee, Rees, Jonathan

Journal:

Year:

2013

Language:

english

File:

PDF, 517 KB

english, 2013

13

Pharmacokinetics and Tolerability of the Novel Oral Prostacyclin IP Receptor Agonist Selexipag

Kaufmann, Priska, Okubo, Kaori, Bruderer, Shirin, Mant, Tim, Yamada, Tetsuhiro, Dingemanse, Jasper, Mukai, Hideya

Journal:

American Journal of Cardiovascular Drugs

Year:

2015

Language:

english

File:

PDF, 491 KB

english, 2015

14

Importierte Malaria

Willcox, Merlin L., Mant, Jill, O'Dempsey, Tim

Journal:

Year:

2014

Language:

german

File:

PDF, 3.78 MB

german, 2014

15

Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies

Martin, Paul, Gillen, Michael, Millson, David, Oliver, Stuart, Brealey, Clive, Elsby, Robert, Baluom, Muhammad, Lau, David, Mant, Tim

Journal:

Clinical Therapeutics

Year:

2015

Language:

english

File:

PDF, 418 KB

english, 2015

16

Effects of CYP3A4 Inhibitors Ketoconazole and Verapamil and the CYP3A4 Inducer Rifampicin on the Pharmacokinetic Parameters of Fostamatinib: Results from In Vitro and Phase I Clinical Studies

Martin, Paul, Gillen, Michael, Millson, David, Oliver, Stuart, Brealey, Clive, Grossbard, Elliott B., Baluom, Muhammad, Lau, David, Sweeny, David, Mant, Tim, Craven, Kelli

Journal:

Year:

2016

Language:

english

File:

PDF, 611 KB

english, 2016

17

Maximum Tolerated Dose and Pharmacodynamics of Eptastigmine in Elderly Healthy Volunteers

Mant, Tim, Troetel, William M., Imbimbo, Bruno P.

Journal:

Journal of Clinical Pharmacology

Year:

1998

Language:

english

File:

PDF, 1.48 MB

english, 1998

18

Investigation of Potential Pharmacodynamic and Pharmacokinetic Interactions Between Selexipag and Warfarin in Healthy Male Subjects

Bruderer, Shirin, Okubo, Kaori, Mukai, Hideya, Mant, Tim, Dingemanse, Jasper

Journal:

Clinical Therapeutics

Year:

2016

Language:

english

File:

PDF, 328 KB

english, 2016

19

Safety, tolerability, pharmacokinetics, and efficacy of AMG 403, a human anti-nerve growth factor monoclonal antibody, in two phase I studies with healthy volunteers and knee osteoarthritis subjects

Gow, Jason M., Tsuji, Wayne H., Williams, Gary J., Mytych, Daniel, Sciberras, David, Searle, Shawn L., Mant, Tim, Gibbs, John P.

Journal:

Arthritis Research & Therapy

Year:

2015

Language:

english

File:

PDF, 819 KB

english, 2015

20

Comparison of the pharmacokinetics, safety, and immunogenicity of MSB11022, a biosimilar of adalimumab, with Humira® in healthy subjects

Hyland, Elizabeth, Mant, Tim, Vlachos, Pantelis, Attkins, Neil, Ullmann, Martin, Roy, Sanjeev, Wagner, Volker

Journal:

British Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.05 MB

english, 2016

21

PRT062607 Achieves Complete Inhibition of the Spleen Tyrosine Kinase at Tolerated Exposures Following Oral Dosing in Healthy Volunteers

Coffey, Greg, Rani, Aradhana, Betz, Andreas, Pak, Yvonne, Haberstock-Debic, Helena, Pandey, Anjali, Hollenbach, Stanley, Gretler, Daniel D., Mant, Tim, Jurcevic, Stipo, Sinha, Uma

Journal:

Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 1004 KB

english, 2016

22

Hormone Replacement Therapy: Characteristics of Users and Non-Users in a British General Practice Cohort Identified through Computerised Prescribing Records

Tim Lancaster, Geraldine Surman, Martin Lawrence, David Mant, Martin Vessey, Margaret Thorogood, Patricia Yudkin and Edel Daly

Journal:

Journal of Epidemiology & Community Health

Year:

1995

Language:

english

File:

PDF, 1.35 MB

english, 1995

23

Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function

Gao, Yifang, Arkwright, Peter D., Carter, Rachel, Cazaly, Angelica, Harrison, Rebecca J., Mant, Alexandra, Cant, Andrew J., Gadola, Stephan, Elliott, Tim J., Khakoo, Salim I., Williams, Anthony P.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 761 KB

english, 2016

24

Biomarkers of 12 SQ House Dust Mite Sublingual Immunotherapy (SLIT)-Tablet Treatment After Nasal Allergen Challenge

Gunawardana, Natasha C., Jain, Ashish, Zhao, Qing, Tsai, Kuenhi, George, Laura, Selverian, Diana, Carayannopoulos, Leon N., Lund, Kaare, Clarke, Graham, Mant, Tim, Hansel, Trevor T., Nolte, Hendrik

Journal:

Journal of Allergy and Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 125 KB

english, 2017

25

Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy

Pasi, K. John, Rangarajan, Savita, Georgiev, Pencho, Mant, Tim, Creagh, Michael D., Lissitchkov, Toshko, Bevan, David, Austin, Steve, Hay, Charles R., Hegemann, Inga, Kazmi, Rashid, Chowdary, Pratima,

Journal:

New England Journal of Medicine

Year:

2017

Language:

english

File:

PDF, 396 KB

english, 2017

26

The effects of house dust mite sublingual immunotherapy (SLIT)-tablet effects on immunological biomarkers and nasal allergen challenge symptoms

Gunawardana, Natasha C., Zhao, Qing, Carayannopoulos, Leonidas N., Tsai, Kuenhi, Malkov, Vladislav A., Selverian, Diana, Clarke, Graham, Mant, Tim, Butts, Brent, Lund, Kaare, Hansel, Trevor T., Nolte,

Journal:

Journal of Allergy and Clinical Immunology

Year:

2017

Language:

english

File:

PDF, 1.36 MB

english, 2017

27

Polypharmacy and Unplanned Hospitalizations in Patients with Rheumatoid Arthritis

Filkova, Maria, Carvalho, João, Norton, Sam, Scott, David, Mant, Tim, Molokhia, Mariam, Cope, Andrew, Galloway, James

Journal:

The Journal of Rheumatology

Year:

2017

Language:

english

File:

PDF, 1.65 MB

english, 2017

28

Pharmacokinetic equivalence, comparable safety, and immunogenicity of an adalimumab biosimilar product (M923) to Humira in healthy subjects

Hillson, Jan, Mant, Tim, Rosano, Molly, Huntenburg, Carolyn, Alai-Safar, Mehrshid, Darne, Siddhesh, Palmer, Donna, Pavlova, Borislava G., Doralt, Jennifer, Reeve, Russell, Goel, Niti, Weilert, Doris,

Journal:

Pharmacology Research & Perspectives

Year:

2018

Language:

english

File:

PDF, 1.96 MB

english, 2018

29

Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvβ6 inhibitor, in healthy participants

Maden, Charlotte H., Fairman, David, Chalker, Michelle, Costa, Maria J., Fahy, William A., Garman, Nadia, Lukey, Pauline T., Mant, Tim, Parry, Simon, Simpson, Juliet K., Slack, Robert J., Kendrick, St

Journal:

European Journal of Clinical Pharmacology

Year:

2018

Language:

english

File:

PDF, 575 KB

english, 2018

30

[American Thoracic Society American Thoracic Society 2010 International Conference, May 14-19, 2010 â¢ New Orleans - ()] B35. AIRWAY INFLAMMATION AND HYPERRESPONSIVENESS - Biomarkers Of Inflammation In Asthma: Predicting The Late Asthmatic Response

Clarke, Graham W., Greenaway, Steven D., Allen, Elisabeth M., Wilbraham, Darren, Mant, Tim G.K.

Year:

2010

File:

PDF, 18 KB

2010